Mt. Healthy is commonly known among Cincinnati natives for serving as a sanctuary from the cholera epidemic. Cincinnati was hit hard in 1849. Away from the river and the congestion surrounding it, there was room to breathe in Mt. Healthy. Citizens fled north and took refuge in this place, which, at that time, was known as Mt. Pleasant.

Mt. Pleasant saw fit to change its designation due to confusion resulting from another nearby locale that was also called Mt. Pleasant. A well-known stop on the Underground Railroad, residents continue to embrace diversity and freedom to this day.