Startups aren't just for Silicon Valley anymore. As entrepreneurs find expected pleasures—and great quality of life—in cities like Cincinnati, a new kind of energy is building. Read about the rise of our startup sister cities, from Boston to Denver.

Nick Shah, who will graduate from the University of Cincinnati later this month, has already proven himself a 21st century Renaissance man. With a degree in biomedical engineering and a minor in Spanish, he'll start med school at UC this year, but he's already a fixture at the Ronald McDonald House, where he shares his talents as a pianist every week. Shah chats with Soapbox about his plans for the future and what he hopes to contribute to the world of medicine.

On the site where the first brewery in Over-the-Rhine began operating in 1829, a new generation of artisans is redefining the boundaries of the historic neighborhood’s 21^st century renaissance.