Corryville : Innovation + Startup News

Researchers at the University of Cincinnati have developed tiny, solar-powered water filters that target and remove carcinogens and antibiotics from lakes and streams.

These protein-based filters are smaller in diameter than a human hair, and work differently than current surface water filters that are made of activated carbon. Those carbon filters work much like the ones in home water filtration systems.

"In Cincinnati, we have one of the largest activated carbon treatment facilities in the United States," says David Wendall, a faculty researcher and environmental engineering professor at UC. "But what the current filters do is bind a lot of different [non-dangerous] compounds; it will will coat the filter very quickly."

UC's research was published in the "Nano Letters" journal. It showed the new filters absorbed 64 percent surface water antibiotics, compared to 40 percent absorbed by current filtering technology.

The research is important because there is growing scientific evidence of harmful effects of the hormones and antibiotics that work their way into our lakes and streams.

"We're starting to understand that birth control is feminizing fish, and antibiotics promote resistance in certain organisms," says Wendall. "It's what is contributing to superbugs that resist to antibiotic treatment. We're learning more about what happens when we dump antibiotics into the environment."

Generally, the contaminates arrive in waterways from runoff through farms or when we flush or trash our medicines.

"The main sources are from farms," Wendall says. "They put antibiotics in animal feed so they will grow fast and stay healthy. But some of their waste ends up in the rivers as runoff, where [the antibiotics] don't break down, and it ends up contaminating our water."

The filter at UC was developed in 2010. Testing has proven successful in specifically targeting antibiotics and other harmful materials.

Wendall describes the filters as "selective garbage disposals." Filtering ability is fueled by sunlight, and the filters actually preserve antibiotics in a way that famers can reuse if filters are recovered.

The university's research is continuing to be tested and refined, Wendall says. But current work could be used practically in three to five years.

By Feoshia H. Davis
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A University of Cincinnati professor is one of three leading investigators in a national study that is comparing two treatments for Post Traumatic Stress Disorder, or PTSD.

The 17-site, $9 million study will take about three years to complete, and it will involve approximately 500 veterans at VA medical facilities across the country, says UC Clinical Psychiatry Professor Kathleen Chard.

Researchers will compare two proven PTSD treatments:

Prolonged Exposure (PE), which allows patients to work through painful memories by re-experiencing traumatic events in  safe and supportive environments, and to engage in activities they've avoided because of trauma. Prolonged exposure also emphasizes education about treatment, common reactions to trauma and breath retraining.

Cognitive Processing Therapy (CPT), which focuses on patients' thoughts and feelings. This approach emphasizes how traumatic experiences changed the patients' thoughts and beliefs, and how those thoughts influence current feelings and behaviors. Patients identify and challenge unhelpful thoughts through structured therapy sessions and practice assignments.

The Institute of Medicine and the health arm of the National Academy of Sciences have endorsed both PSTD treatments, which are used for both military and civilian patients. One of the study's goals will be to determine which treatment works better when a patient has other problems, like depression or substance abuse.

Chard is co-author of the CPT military/veteran manual and the national CPT implementation director for the Department of Veterans Affairs.

"Both are gold standard treatments, but what we don't know is, if I have patient 'X,' which one should I put them in," she says. "What we have now is informed patient choice. We tell them about the treatments and they can decide what to do. We don't have solid research about what works best."

Chard is also director of UC's Department of Psychiatry and Behavioral Neuroscience PTSD division, which is based at the Cincinnati Department of Veterans Affairs (VA) Medical Center facility in Ft. Thomas. It likely will be one of the 17 testing sites.

The findings of the study will have an impact that reaches beyond treatment for members of the military, as PTSD has been diagnosed in people who have never been in the miliary, but who have seen or lived through dangerous events, including survivors of physical and sexual assault, abuse, accidents and natural disasters.

By Feoshia H. Davis
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Rebecca Huffman’s circuitous route to UC’s Fashion Design program both inspired and informed her non-traditional senior thesis, Design Genius. More methodology than consumer good, Design Genius is a learning module that teaches students the value of education and the building blocks of problem-solving as they design their own products.

Unveiled at UC’s DAAPWorks, Design Genius takes a fresh approach to making learning relevant for kids of all ages, which is exactly what recent grad Huffman, 24, who works for LPK, wanted. 

“I knew that I wanted to do something that would help kids,” says Huffman, who spent a year working as a preschool teacher before starting her design training at DAAP.

As she considered what her culminating project for college would be, she thought back to a studio class in which she’d designed and created a real project, then put it up for sale in real life. Through that process, and its embrace of design-thinking, she saw the value of the disparate classes she’d taken through her academic career, from math to marketing and writing to psychology. And she felt empowered.

Her work as an LPK co-op increased her experience with design-thinking, an approach to problem-solving more often seen in Fast Company than elementary schools. 

“Design Genius is an attempt to solve the problem that our kids are facing by instilling a greater sense of educational purpose,” she says. 

She describes Design Genius on her website as “the culmination of five years of study and extensive research on the Creativity Quotient, Design Thinking in education, the concept of ‘failing forward,’ sociocultural trends impacting Generation Z, and the educational and social development of Tweens.”

What that looked like, in the end, were three, one-and-a-half hour sessions in two schools—St. Ursula Villa and Pleasant Ridge Montessori—in three different classes. Fourth and fifth grade students examined case studies in the form of fictional diary entries. Then, they ideated, revised and designed real products to help solve the problems of their fictional “customers.” 

“They learned everything I was trying to teach them,” Huffman says. “It was amazing.”

The students not only learned from the project, they loved it. Huffman received unprompted thank-you notes and testimonials when the students presented their products. She’s convinced that with a little tweaking, she can develop a fully functional learning module that can help young students not only design products, but create and sell them. 

By Elissa Yancey
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Today, Detroit-based Digerati launches its Intern in Ohio program to the public, which is sponsored by the University of Toledo. Like eHarmony, the program uses an advanced matching algorithm to match students with internship opportunities.
 
Intern in Ohio is free to both students who are looking for internships and businesses who want to post internships. To register, students and employers visit Intern in Ohio’s website to sign up and create a profile or post internship opportunities. Students fill out a short questionnaire about their preferences, and employers share information about the position. The system then identifies the top seven matches for each student, as well as for each position. When the match is made, both the student and employer are notified, and they must show interest before any contact information is shared.
 
“We encourage diverse companies—large and small, for-profit and nonprofit, government and corporate,” says Wendy Pittman, director of Digerati’s Classroom to Career. “It’s a great chance for employers to broadcast their company and internship program across the state and reach a larger pool of applicants.”
 
Only companies in Ohio can post opportunities to the Intern in Ohio website, but all types of internships are welcome. There are posts for marketing, engineering and social media, among others, says Pittman.
 
The program is open to all students who live in Ohio, whether they’re in-state or out-of-state students. Research shows that not only do internships often lead employment offers after graduation, but that students are more likely to remain in an area where they held and internship.
 
“This is the first replication of the Classroom to Career technology from Michigan to Ohio,” says Pittman. “Experiential learning is a game-changer; and we’re looking forward to working with smaller communities to make a difference.”
 
In 2011, Digerati launched its Intern in Michigan program, which has resulted in more than 127,000 matches and introductions between students and employers. Over 1,000 Michigan businesses have posted 4,824 internship opportunities, and 1,049 colleges and universities in the state use the site.
 
Full disclosure: Soapbox’s parent company, IMG, supplies content to Intern in Ohio on a contractual basis.
 
By Caitlin Koenig
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Going on maternity leave changed Gail Yisreal’s life in more ways than having a new baby to take care of.
 
When she returned to work, Yisreal says she learned her position was no longer there, so she began to look for a different job.

As wife and mother to a blended family of nine children, she might bake up to 11 birthday cakes in a year. But she hadn’t considered turning her knack for kneading dough into earning dough until she baked a wedding cake for a couple from her family’s place of worship. Not only did they like the cake, they suggested she start selling them.
 
Listening to her fans, Yisreal founded A “Mother’s Touch” Cakes with the nurturing tagline, “Making fresh homemade cakes when you don’t have the time.” Celebrating her two-year anniversary as a registered business in August 2012, A “Mother’s Touch” features signature and custom made flavors of fresh, savory gourmet, organic and vegan cakes and cupcakes that are good—and good for you.
 
“I didn’t know anything about decorating, so I took a class to learn more decorating skills," Yisreal says. "And I was shocked to find out that 95 percent of the cakes you buy are box cakes—because everybody wants the decoration. I started doing some research about the trans-fats and artificial ingredients, and I vowed that everything I baked would always be natural and from scratch.”  
 
After working as a waitress for two years and in management at Starbucks for six years, Yisreal developed a love for coffee. She jokes that most ex-Starbucks managers feel they know enough about coffee to create their own line, which she actually did for A “Mother’s Touch.”
 
Having tried organic coffees with weak flavor profiles, she researched and found Dean’s Beans, a fair-trade pioneer that allowed her to design her own custom blends. Her signature A “Mother’s Touch” blend is made with Mexican and Indonesian beans and pairs with her carrot cake as an after-dinner coffee.
 
“I’m really proud of my coffee and the fact that it really was custom blended for what I wanted to complement my desserts,” Yisreal says. And, true to her mission to serve natural, sustainable goods, she says that her blends are 100 percent organic, fair-trade certified and are shade grown.
 
Being on the scene without a storefront hasn’t stopped Yisreal. Instead, she’s building her brand as the “cupcake lady” who networks everywhere and invites people to taste samples of her creations. Yisreal also tapped into hidden markets by hosting deals through social media.
 
“I did a Living Social promotion last year, which was huge,” Yisreal says. “That first day, I think I got 1,500 hits on my website, and probably about 85 deals, which I thought was really good for people who didn’t know who I was.”
 
And even though she sells more cakes today, the ease of transporting cupcakes built her clientele.
 
“When I first came out, because of my financial situation, literally, cupcakes were paying my rent,” she says. After she and her husband separated, she remembers what it was like to go from making an annual salary of $60,000 to less than $20,000 a year. But she doesn’t do it all alone.
 
“I have three almost-teenage girls; 12, soon to be 15 and 17, so they are my preppers,” Yisreal explains. “It’s hilarious because we’ll be in the kitchen and everybody has their big bonnets on, and they’re scraping carrots, mashing fruit, lining the liners. I have a girlfriend who I’ll sometimes sub-contract out to do deliveries. And if it’s a huge event—like for the Autism Foundation, I had to knock out 40 dozen cupcakes—I have two sisters, and at the time I had just split up with my husband so we were in literally an 800-square-foot apartment. The kitchen was all of maybe 150-square-feet, we put out six-foot tables and we were like an assembly line! It was hilarious, but we got it done. It was like an I Love Lucy episode!”
 
By Mildred Fallen

A virtual trade mission taken by University of Cincinnati MBA students and local industries has turned into a very real product that could put a dent in food shortages across India.

Next year, new solar-powered refrigerator products will be tested on an aloe farm in the developing country early next year. If successful, the SolerCool could be a reality for Indian farmers, just in time for summer.

The product is a self-contained cooling unit that relies on the sun for power. It's a box that measures 10' x 7' x 11', and is topped by solar panels. SolerCool was developed through a collaboration between former and current UC students and local industries, including SimpliCool Technologies International LLC in Waynesville.

The idea for the technology came after the MBA students and SimpliCool attended a "virtual trade mission" to India in July 2011. The mission was part of a Business Law for Managers class taught by Ilse Hawkins, an attorney and adjunct professor of accounting at UC. The mission virtually brought Cincinnati and Indian businesses together to find ways of partnering to better preserve Indian produce.

Today, 30 to 40 percent of produce in India is lost to spoilage because of lack of refrigeration options, Hawkins says. India, with 1.2 million people, faces chronic food shortages.

"While we were doing the mission, we had this tiny, insulated structure that kept audio visual materials at proper temperature," Hawkins says. "We thought, 'Why couldn't we create a structure powered with solar panels like that that could be put anywhere on a farm?'"

Shortly after that meeting, Hawkins took a group to India where the idea was further flushed out. Eventually, a collaborative effort led to the creation of the SolerCool unit.

MBA students worked on a business plan, helped with the initial feasibility calculations and networked with Indian businesses who might contribute to the product.

Mohsen Rezayat, chief solutions architect at Siemens UGS PLM Software and adjunct professor in UC’s College of Engineering and Applied Science, primarily worked on the engineering of the solar panels in the SimpliCool-manufactured cooling cube.

UC does not own the product, and therefore won't be profiting from its sales, Hawkins says. However, SimpliCool has vowed to contribute to UC's College of Business to fund further travel to India if the idea is successful, she says.

By Feoshia H. Davis
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A group of University of Cincinnati faculty and students will go to Iraq in November as part of a collaboration between U.S. and Iraq university to strengthen educational and economic opportunities in the Middle East county.

Starting Nov. 2, representative from UC's College of Education, Criminal Justice and Human Services (CECH) and the UC Career Development Center (CDC) will go to Salahaddin University-Hawler in Erbil, Iraq.

It's the latest in a series of trips between the two universities, which are in the third year of a U.S. State Department-sponsored linkages program geared toward undergraduate Iraqi students. Originally scheduled to end this year, the collaboration was given a six-month extension, says Laura Dell, academic director of distance learning for the UC School of Education.

"I'm going to be teaching a two-week long seminar on education research. We'll also be observing teaching in classrooms and providing peer feedback," Dell says.

The universities will also plan a joint spring conference.

UC faculty will lead career development workshops, providing feedback on research courses, discussing literature and exploring future opportunities for post-doctoral students.

Theresa Aberle, adjunct instructor and program coordinator for the UC Career Development Center, will help lead a conference on creating career centers.

"I'll be there with four Iraqi universities and four U.S. universities. We'll be sharing information on how to set up career centers, how to do presentations and marketing, and all the different pieces of what a takes to get a career center working," Aberle says.

As Iraq is transitioning into a more democratic government form, privates businesses are moving in and looking for a workforce. It's a cultural shift for the country that encompasses many important topics, including career development.

"They've never had to have a career center before; it's a whole new venture for them," Aberle says.

UC is among only five U.S. institutions picked to partner with five Iraqi universities. The partnership fits in with UC's 2019 strategic plan to expand international partnerships and overseas research collaborations.

"It's part of the mission to help wherever we can," Dells says.

Salahaddin University-Hawler is in the Kurdish region of Iraq, where many natives speak English as a second language, Dell says. That's made it much easier for each side to communicate and work together. Located in the Northern part of Iraq, it's also not as subject to ongoing violence. This is Dell's second trip there.

"What we see of Iraq on the news is violence, and upheaval. It's been really nice to see the other side of the Middle East. People are excited to talk to Americans and very nice," she says.

By Feoshia H. Davis
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It would appear that not all native Ohioans dread the scorching summers typical in our region. In fact, members of UC’s biology department recently identified two plants that thrive under the same conditions that send humans running for air-conditioned shelter.

A pilot study conducted by UC biology student Jill Bader and assistant professor of biology Ishi Buffam found that of four native Ohio plants tested, the nodding wild onion (Allium cernuum) and a European sedum (Sedum acre) are particularly well suited for the vegetated roofs becoming increasingly common—and which the pair hope to help popularize even further—in local green building practices.

Green roofs have been utilized in many cities to address environmental issues, from air pollution and street noise to excess stormwater runoff. According to Buffam, however, most of the plants currently used on green roofs are not native to the region.

“We aim to help inform policy and details of green roof construction and implementation by increasing the knowledge base,” Buffam says.

The results of the study, which Buffam and Bader presented earlier this month at the CitiesAlive 2012 conference in Chicago, confirm earlier studies which have found the nodding wild onion to be a successful green roof plant.

“It was exciting to see everyone coming together to share research data, case studies and ideas for increasing green roof adoption as a solution for the environmental issues created by urbanization,” Bader says.

“In order for green roof installations to become more widely adopted in the region, more guidance supported by research data is needed,” says Buffam. “Especially as it relates to the selection of green roof plants and the ecosystem services they provide. [Such research] is extremely important to the efforts of municipalities, businesses and environmental agencies who utilize green roofs in their efforts at reducing stormwater runoff and protecting the quality of our surface waters.”

Buffam and Bader direct those interested in learning more about green roofs to the Civic Garden Center’s Green Learning Station, a roundup of  “…responsible methods to grow gardens anywhere and everywhere: yards, rooftops, walls, patios, driveways and parking lots.”

By Hannah Purnell

Fifteen years after opening its doors, BIOSTART, Cincinnati's life sciences start-up center, is changing the way it does business. In order to remain competitive in a fast-changing business market, it is closing its lab space and moving from its location near the University of Cincinnati.

BIOSTART President Carol Frankenstein says the organization will focus exclusively on business services, making the hard shift as its closes its current facility at the Hoxworth Blood Center in September. She says the change was both a business and a strategic decision.

"Today, companies, even at the very early stages, are outsourcing their commercialization and development activity. That includes clinical and preclinical work, development and manufacturing," Frankenstein says. "That increase in outsourcing reduces the cost of getting a product to market. That makes lab space less necessary. Because of the economy, there is so much low-cost and even free space available; our companies have the ability to benefit from that."

BIOSTART serves life sciences entrepreneurs in health care service and product development. Since 1996, it's helped 125 companies launch their business and raise $180 million. Three-fourths of those businesses have had successful exits or are currently in business, the organization reports.

BIOSTART is working with local business advocates, including the Hamilton County Business Center, Uptown Consortium and CincinnatiUSA Regional Chamber to help its 18 tenant companies (which occupy about 65 percent of its space) to relocate.

Frankenstein said BIOSTART is looking for a new space downtown. She will remain with the organization as will three entrepreneurs in residence. The organization has received $500,000 in funding, half from the Ohio Department of Development and half from private sources, to aid in the transition.

"We're using the grant for the next 12 months to explore new service delivery models," she says.

BIOSTART's current business services include helping companies put together a management team and connecting with and applying for funding sources.

By Feoshia Henderson

You can follow Feoshia on Twitter @feoshiawrites

Independent studies show that an ADHD drug developed by P2D Bioscience treats core symptoms of the disorder with fewer side effects than current, comparable drugs.

Two pre-clinical studies suggest the company's PD2005 is as effective as amphetamine and methylphenidate in treating ADHD. The studies show PD2005 improve both sustained attention and working memory, but has lower side effects, including risk of addiction. The studies were funded by a grant from the National Institutes of Health, according to the company.

"The primary criticism of current first-line ADHD treatments is their side effects," P2D CEO Dr. Frank Zemlan. "The treatments are Schedule II drugs of abuse prescribed mainly to children. In contrast, a unique feature of P2D's lead ADHD compounds is that they demonstrate no abuse potential in the 'Gold Standard' of preclinical abuse liability testing."

The treatment of ADHD is a $3.5 million market; Dr. Zemlan believes a drug with less side effects will appeal to parents reluctant to treat their children's symptoms.

Dr. Zemlan predicted, "A new ADHD drug without the side effect burden of current first line ADHD drugs will dominate the ADHD market," he said.

P2D Bioscience is a privately held P2D pharmaceutical company that specializes in developing drugs that treat a range of disorders including ADHD, obesity, anxiety, depression and Alzheimer's disease and more. The company is based in Corryville and is managed by a team with decades of experience in drug discovery, clinical research and technology transfer.

Writer: Feoshia Henderson
Source: P2D Bioscience

You can follow Feoshia on Twitter @feoshiawrites